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匹配条件： “Catherine K. Hagandora” ，找到相关结果约185173条。
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A Comparison of the Mechanical Properties of the Goat Temporomandibular Joint Disc to the Mandibular Condylar Cartilage in Unconfined Compression
Catherine K. Hagandora,Thomas W. Chase,Alejandro J. Almarza
Journal of Dental Biomechanics , 2011, DOI: 10.4061/2011/212385

Abstract:

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Does Current Nephrology Fellowship Training Affect Uti-lization of Peritoneal Dialysis in the United States? [PDF]
Nand K. Wadhwa, Catherine R. Messina, Nasser M. Hebah
Open Journal of Nephrology (OJNeph) , 2013, DOI: 10.4236/ojneph.2013.32019

Abstract:

Background: The 2010 US Renal Data System annual report revealed that peritoneal dialysis is used by only 7% of end-stage renal disease patients on chronic dialysis vs. hemodialysis which is used by 93% of such patients, despite documented benefits of peritoneal dialysis over hemodialysis in these cases. Purpose: We examined whether education of nephrology fellows contributed to underutilization of peritoneal dialysis in the US. Methods: Self-report questionnaires were administered electronically to nephrology fellowship training program directors, October 2010-March 2011 (55% response). Results: Median number of training faculty and patients/fellow were significantly lower for peritoneal-dialysis vs. hemodialysis training. Hours of didactic teaching for fellows over their 2-year training period were significantly lower for peritoneal dialysis vs. hemodialysis. Peritoneal dialysis training was 20% of total training vs. 80% for hemodialysis. Most program directors (87%) believed lack of trained faculty in peritoneal dialysis and insufficient peritoneal dialysis patient population contributed to inadequate fellows’ peritoneal dialysis training. Conclusions: Findings suggest that current nephrology fellowship training in peritoneal dialysis is inadequate and contributes to its underutilization.

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Hopf algebra gauge theory on a ribbon graph
Catherine Meusburger,Derek K. Wise
Mathematics , 2015,

Abstract: We generalise the notion of a group gauge theory on a graph embedded into an oriented surface to finite-dimensional ribbon Hopf algebras. By linearising the corresponding structures for groups, we obtain axioms that encode the notions of connections, the algebra of functions on connections, gauge transformations and gauge invariant observables. Together with certain locality conditions, these axioms reduce the construction of a Hopf algebra gauge theory to a basic building block, a Hopf algebra gauge theory for a vertex with n incoming edge ends. The associated algebra of functions is dual to a two-sided twist deformation of the n-fold tensor product of the Hopf algebra. We show that the algebra of functions and the subalgebra of observables for a Hopf algebra gauge theory coincide with the ones obtained in the combinatorial quantisation of Chern-Simons theory, thus providing an axiomatic derivation of the latter. We discuss the notion of holonomy in a Hopf algebra gauge theory and show that for semisimple Hopf algebras this defines a functor from the path groupoid into a certain category associated with the Hopf algebra gauge theory. Curvatures are then obtained as holonomies around the faces of the graph, correspond to central elements of the algebra of observables and define a set of commuting projectors on the subalgebra of observables on flat connections. We show that the algebra of observables and its image under these projectors are topological invariants and depend only on the homeomorphism class of the surface obtained, respectively, by gluing annuli and discs to the faces of the graph.

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Sickle Cell Disease and Pregnancy: Does Outcome Depend on Genotype or Phenotype? [PDF]
Catherine Berzolla, Neil S Seligman, Aisha Nnoli, Kevin Dysart, Jason K Baxter, Samir K Ballas
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.23054

Abstract: Objective: Women with Sickle Cell Disease (SCD) who become pregnant are at risk for serious maternal and fetal complications. Our objective was to determine if pregnancy outcome is dependent on phenotype. Methods: Retrospective cohort study of pregnant women with SCD, including hemoglobin (Hb) SS, Hb SC, and Hb Sβ-thalassemia, between January 1999 and December 2008). Antenatal and neonatal outcomes were compared between pregnancies with painful episodes and those without. The primary outcome was preterm birth (PTB) <37 weeks. Secondary outcomes included maternal medical complications, antenatal complications, delivery outcomes, and neonatal outcomes. Results: 31 women were included (18 (58%) with painful episodes, 13 (42%) without painful episodes). The median number of painful episodes was 2.5 (1 - 19) and these women required a median of 13 total days (1 - 59) of inpatient treatment. At delivery, women who had experienced painful episodes had lower Hb levels and were more likely to be taking chronic narcotic pain medications. The overall incidence of PTB <37wks was 55% and was not significantly different between groups (11 [61%] with painful episodes versus 6 [46%] without painful episodes; p = 0.485). Secondary outcomes were also not significantly different between groups. There was one maternal death. Conclusion: Adverse obstetrical out-comes were more common among women with sickle cell disease who experienced painful crises however, in this small sample, the difference were not statistically significant.

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Co-expression module analysis reveals biological processes, genomic gain, and regulatory mechanisms associated with breast cancer progression
Zhiao Shi, Catherine K Derow, Bing Zhang
BMC Systems Biology , 2010, DOI: 10.1186/1752-0509-4-74

Abstract: We have developed a novel algorithm Iterative Clique Enumeration (ICE) for identifying relatively independent maximal cliques as co-expression modules and a module-based approach to the analysis of gene expression data. Applying this approach on a public breast cancer dataset identified 19 modules whose expression levels were significantly correlated with tumor grade. The correlations were reproducible for 17 modules in an independent breast cancer dataset, and the reproducibility was considerably higher than that based on individual genes or modules identified by other algorithms. Sixteen out of the 17 modules showed significant enrichment in certain Gene Ontology (GO) categories. Specifically, modules related to cell proliferation and immune response were up-regulated in high-grade tumors while those related to cell adhesion was down-regulated. Further analyses showed that transcription factors NYFB, E2F1/E2F3, NRF1, and ELK1 were responsible for the up-regulation of the cell proliferation modules. IRF family and ETS family proteins were responsible for the up-regulation of the immune response modules. Moreover, inhibition of the PPARA signaling pathway may also play an important role in tumor progression. The module without GO enrichment was found to be associated with a potential genomic gain in 8q21-23 in high-grade tumors. The 17-module signature of breast tumor progression clustered patients into subgroups with significantly different relapse-free survival times. Namely, patients with lower cell proliferation and higher cell adhesion levels had significantly lower risk of recurrence, both for all patients (p = 0.004) and for those with grade 2 tumors (p = 0.017).The ICE algorithm is effective in identifying relatively independent co-expression modules from gene co-expression networks and the module-based approach illustrated in this study provides a robust, interpretable, and mechanistic characterization of transcriptional changes.Large-scale gene expression

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Experimental annotation of the human pathogen Histoplasma capsulatum transcribed regions using high-resolution tiling arrays
Mark Voorhies, Catherine K Foo, Anita Sil
BMC Microbiology , 2011, DOI: 10.1186/1471-2180-11-216

Abstract: We employed a three-pronged approach to provide a functional annotation for the H. capsulatum G217B strain. First, we probed high-density tiling arrays with labeled cDNAs from cells grown under diverse conditions. These data defined 6,172 transcriptionally active regions (TARs), providing validation of 6,008 gene predictions. Interestingly, 22% of these predictions showed evidence of anti-sense transcription. Additionally, we detected transcription of 264 novel genes not present in the original gene predictions. To further enrich our analysis, we incorporated expression data from whole-genome oligonucleotide microarrays. These expression data included profiling under growth conditions that were not represented in the tiling experiment, and validated an additional 2,249 gene predictions. Finally, we compared the G217B gene predictions to other available fungal genomes, and observed that an additional 254 gene predictions had an ortholog in a different fungal species, suggesting that they represent genuine coding sequences.These analyses yielded a high confidence set of validated gene predictions for H. capsulatum. The transcript sets resulting from this study are a valuable resource for further experimental characterization of this ubiquitous fungal pathogen. The data is available for interactive exploration at http://histo.ucsf.edu webcite.Histoplasma capsulatum is a dimorphic fungal pathogen that is thought to infect up to 500,000 individuals per year in the U.S[1]. Notably, H. capsulatum is a primary pathogen that causes significant morbidity in immunocompetent hosts[2]. Normally found in a filamentous mycelial form in the soil of endemic regions, H. capsulatum converts to the pathogenic yeast form in the lungs of the host after inhalation of infectious particles (Figure 1). In the laboratory, temperature is a sufficient signal to specify growth in either the mycelial form (at room temperature) or growth in the yeast form, which can be achieved by incubating cells

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Atrial Septal Defect and Left Recurrent Laryngeal Nerve Paralysis: A Case of Ortner’s Syndrome and Literature Review [PDF]
Andrew M. Vahabzadeh-Hagh, Catherine Yim, Jayson Fitter, Dinesh K. Chhetri
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2015, DOI: 10.4236/ijohns.2015.42011

Abstract:

Introduction: Cardiovocal syndrome, or hoarseness resulting from vocal fold paralysis secondary to cardiovascular pathology, is commonly referred to as Ortner’s syndrome. We present a brief overview of vocal fold paralysis, present an illustrative case of Ortner’s syndrome, and provide a review of the pertinent literature. Here we aim to broaden one’s differential for vocal fold paralysis, discuss its importance as pertains to cardiovascular pathology and outcomes, and highlight the difficulties in therapeutic planning for these unique patients. Methods: A case report and literature review. Results: A 26-year-old female with an atrial septal defect and pulmonary hypertension presented with 5 months of hoarseness. Laryngoscopy revealed left vocal fold paralysis. Imaging from the skull base to chest showed an enlarged pulmonary artery (PA) in the absence of other abnormalities. Literature review suggests that this left laryngeal nerve paralysis results from nerve compression within the aortopulmonary window, a triangle defined by the aortic arch, PA, and ligamentumarteriosum. Imaging in our patient over 8 months demonstrated an increase in PA size from 3.9 to 4.2 cm correlating with the onset of hoarseness. Conclusions: Importantly, hoarseness second ary to laryngeal nerve compression in cardiovascular disease may correlate with a poorer prognosis, i.e., in thoracic aortic aneurysms and mitral valvestenosis. Awareness of vocal changes in the setting of cardiovascular disease improves diagnostic acumen in vocal foldparalysis.

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Stochastic acceleration of solitons for the nonlinear Schr？dinger equation
Walid K. Abou Salem,Catherine Sulem
Physics , 2008,

Abstract: The effective dynamics of solitons for the generalized nonlinear Schr\"odinger equation in a random potential is rigorously studied. It is shown that when the external potential varies slowly in space compared to the size of the soliton, the dynamics of the center of the soliton is almost surely described by Hamilton's equations for a classical particle in the random potential, plus error terms due to radiation damping. Furthermore, a limit theorem for the dynamics of the center of mass of the soliton in the weak-coupling and space-adiabatic limit is proven in two and higher dimensions: Under certain mixing hypotheses for the potential, the momentum of the center of mass of the soliton converges in law to a diffusion process on a sphere of constant momentum. Moreover, in three and higher dimensions, the trajectory of the center of mass of the soliton converges to a spatial Brownian motion.

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The Relationship between Energy Literacy and Environmental Sustainability [PDF]
Catherine Dwyer
Low Carbon Economy (LCE) , 2011, DOI: 10.4236/lce.2011.23016

Abstract: Sustainability, first identified as a characteristic of eco-systems, is the capacity to maintain a process indefinitely. Environmental sustainability receives significant public and government attention, triggered by concerns about climate change, decreasing energy supplies, and increasing food costs. Colleges and universities receive positive notice for their greening efforts, and the academy is expected to be a leader in efforts to improve sustainability. Therefore coursework and curricula must be developed to train students about sustainable resource consumption processes. This paper describes curricula materials related to energy literacy, defined as conceptual fluency with the economic and social components of energy use. These materials were developed and piloted over a three year period, and were tested with a pre- and post-course survey administered with questions based on the New Environmental Paradigm (NEP) and Environmentally Responsible Behavior (ERB). The findings of this study suggest that discussion of sustainability with disaster themes triggers anxiety that interferes with the development of ERB. In contrast, materials emphasizing the pragmatic necessity and benefits derived from sustainable practices relate to improvements in ERB. This suggests sustainability curricula should mitigate anxiety aroused by the topic, and instead emphasize pragmatic motivations for changing energy consumption patterns.

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Film Subtitles as a Successful Vocabulary Learning Tool [PDF]
Catherine Kanellopoulou
Open Journal of Modern Linguistics (OJML) , 2019, DOI: 10.4236/ojml.2019.92014

Abstract: Films are a valuable source of authentic language material, but what makes them superior to other types of authentic materials is the existence of a full storyline which leads to the increased engagement of the viewer. Despite the fact that teachers intuitively know this particular activity which may enhance language learning there is little research that has sought to thoroughly examine its potential impact on vocabulary acquisition and retention. While most studies conclude that the type of subtitling is an important factor influencing vocabulary learning; defining which particular type of subtitling is most effective seems difficult to determine and results in this area are somewhat inconclusive. Further research is, therefore, necessary to determine which type of subtitling would lead to optimum results in vocabulary acquisition and retention.

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